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基本信息

 
吴洁
工程力学系
电子邮件-Email:jiewu82@sjtu.edu.cn

个人简历

 
研究经历
2012/01-至今,上海交通大学船舶海洋与建筑工程学院工程力学系,助理研究员
2010/01-2012/01,上海交通大学船舶海洋与建筑工程学院工程力学系,博士后

教育经历
2001/09-2009/06,复旦大学力学系,本硕博
2007/07-2008/07,英国布鲁内尔大学生物工程学院,博士生联合培养

研究方向

 
生物力学

学术兼职

 

科研项目

 
1.国家自然科学基金面上项目,No.11572200,生理流动条件下CD82-EWI2介导的乳腺癌细胞粘附转移的机制研究,2016/01-2019/12,79万,主持。
2.国家自然科学基金面上项目,No.11372191,循环癌细胞力学特性对癌症转移影响的机理研究,2014/01—2017/12,86万,参加。
3.国家自然科学基金青年基金项目,No.51206108,新型微控芯片中单细胞趋化运动及影响机制研究,2013/01—2015/12,25万,参加。
4.国家自然科学基金青年基金项目,No.11102113,HER-2+乳腺癌微环境流动对靶向药物结合影响的模型和实验研究,2012/01-2014/12,28万,主持。
5.中国博士后科学基金项目,No.20100470702,肿瘤血液微循环流动状态下脂质体与血管内皮细胞结合效率的模拟研究,2010/06-2012/06,3万,主持。

代表性论文及专著

 
Jie Wu*, Maolan Li, Yijian Zhang, et al. Molecular mechanism of activated T cells in breast cancer. OncoTargets and Therapy, 2018, v11: 5015–5024.
Jie Wu*, Yan Cai, Gaiping Zhao. Bioinformatics analysis of changes in RNA polymerase II transcription stimulated by estradiol in MCF7 cells. Neoplasma, 2018, 65(1): 14-20.
Fan Bai, Jie Wu, Ren Sun*. An investigation of endocytosis of targeted nanoparticles in a shear flow by a statistical approach. Math Biosci 2018, 295: 55-61.
Jie Wu*, Yan Cai, Maolan Li, et al. Oxymatrine Promotes S-Phase Arrest and Inhibits Cell Proliferation of Human Breast Cancer Cells in Vitro through Mitochondria-Mediated Apoptosis. Biol Pharm Bull, 2017, 40(8): 1232-1239.
Yan Cai, JieWu, Zhiyong Li, et al. Mathematical Modelling of a Brain Tumour Initiation and Early Development: A Coupled Model of Glioblastoma Growth, Pre-Existing Vessel Co-Option, Angiogenesis and Blood Perfusion. PLOS ONE, 2016, v3: 0150296.
Jie Wu*, Zhujun Tan, Jian Chen, et al. Cyclovirobuxine D Inhibits Cell Proliferation and Induces Mitochondria-mediated Apoptosis in Human Gastric Cancer Cells. Molecules, 2015, 20: 20659–20668.
Jie Wu*, Yan Cai, Yi Fu, et al. 3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization. Appl Math Mech (-Engl Ed), 2015, 36: 153–162.
Yan Cai, Jie Wu, Zhiyong Li. A coupled mathematical model of cell migration, vessel cooption and tumour microenvironment during the initiation of micrometastases. Mol Cell Biomech, 2015, 12: 231-248.
Yi Fu, Jianhua Wu, Jie Wu, et al. Micro-PIV Measurements of the Flow Field around Cells in Flow Chamber. J Hydrodynamics, 2015, 27: 562-568.
Yan Cai, Jie Zhang, Jie Wu, et al. Oxygen transport in a three-dimensional microvascular network incorporated with early tumour growth and preexisting vessel cooption: numerical simulation study. BioMed Res Inter, v2015, Artical ID 476964.
Yan Cai, Jie Wu, Shixiong Xu, et al. A hybrid cellular automata model of multicellular tumour spheroid growth in hypoxic microenvironment. J Appl Math, 2013, v2013, Article ID 519895.
Yan Cai, Jie Wu, Quan Long, et al. 3D numerical simulation of avascular tumour growth: effect of hypoxic microenvironment in host tissue, Appl Math Mech (-Engl. Ed.), 2013, v34(9), 1055–1068.
Jie Wu*, Cheng Dong, Zurong Ding, et al. Simulation of tumor vasculature and microenvironment in response to vascular-disruting drug treatment. Mol Cell Biomech, 2012, 9(2): 95~126.
Jie Wu, Quan Long, Shixiong Xu. Chapter 14: Blood perfusion in solid tumor with “normalized”microvasculature. In: Modeling Tumor Vasculature. T.L. Jackson Ed. Springer Publisher, 2012.
Jie Wu*, Zurong Ding, Yan Cai, et al. Simulation of tumor microvasculature and microenvironment in response to anti-angiogenic treatment by angiostatin and endostatin. Appl Math Mech, 2011, vol.32 (4): 437-448.
Yan Cai, Jie Wu, et al. Numerical simulation of the inhibiting effects on solid tumour cells in anti-angiogenic therapy: an application of coupled mathematical model of angiogenesis with tumour growth. Appl Math Mech, 2011, 32(10), 1287–1296.
Yan Cai, Shixiong Xu, Jie Wu, et al. Coupled modelling of tumour angiogenesis, tumour growth and blood perfusion. J Theor Biol, 2011, v279: 90–101.
Jie Wu, Quan Long, Shixiong Xu, et al. Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature. J Biomech, 2009, 42: 712-721.
Jie Wu, Shixiong Xu, Quan Long, et al. Coupled modeling of blood perfusion in intravascular, interstitial spaces in tumour microvasculature. J Biomech, 2008, 41: 996-1004.
Jie Wu, Shixiong Xu, Quan Long, et al. Simulation of 3D Solid Tumour Angiogenesis Including Arteriole, Capillary and Venule. Mol & Cell Biomech, 2008, 5(4): 127-227.

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研究生课程《生物流体力学》

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